Loss of tolerance to gut immunity protein, glycoprotein 2 (GP2) is associated with progressive disease course in primary sclerosing cholangitis

Glycoprotein 2[GP2] is a specific target of pancreatic autoantibodies[PAbs] in Crohn’s disease(CD) and is involved in gut innate immunity processes. Our aim was to evaluate the prevalence and prognostic potential of PAbs in primary sclerosing cholangitis(PSC). Sixty-five PSC patients were tested for...

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Bibliographic Details
Published in:Scientific reports 2018-01, Vol.8 (1), p.399-399, Article 399
Main Authors: Tornai, Tamas, Tornai, David, Sipeki, Nora, Tornai, Istvan, Alsulaimani, Rayan, Fechner, Kai, Roggenbuck, Dirk, Norman, Gary L., Veres, Gabor, Par, Gabriella, Par, Alajos, Szalay, Ferenc, Lakatos, Peter Laszlo, Antal-Szalmas, Peter, Papp, Maria
Format: Article
Language:English
Subjects:
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Adolescent
Adult
Autoantibodies
Autoantibodies - metabolism
Cholangitis
Cholangitis, Sclerosing - immunology
Crohn's disease
Cytometry
Disease Progression
Female
Glycoproteins
GPI-Linked Proteins - immunology
Humanities and Social Sciences
Humans
Immunity (Disease)
Immunofluorescence
Immunoglobulin A
Immunoglobulin A - metabolism
Immunological tolerance
Innate immunity
Liver diseases
Male
Mucosa
multidisciplinary
Pancreas
Prognosis
Prospective Studies
Science
Science (multidisciplinary)
Secretory component
Translocation
Young Adult
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Summary:Glycoprotein 2[GP2] is a specific target of pancreatic autoantibodies[PAbs] in Crohn’s disease(CD) and is involved in gut innate immunity processes. Our aim was to evaluate the prevalence and prognostic potential of PAbs in primary sclerosing cholangitis(PSC). Sixty-five PSC patients were tested for PAbs by indirect immunofluorescence and compared with healthy (n = 100) and chronic liver disease controls(CLD, n = 488). Additionally, a panel of anti-microbial antibodies and secretory (s)IgA levels were measured, as markers of bacterial translocation and immune dysregulation. PAbs were more frequent in PSC(46.2%) compared to controls(healthy:0% and CLD:4.5%), [P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-18622-1