Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry

OBJECTIVE:This study examines asthma risk in facilities producing toluene diisocyanate (TDI). METHODS:A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures. RESULTS:The incidence of cases consistent with TDI-induced asthma was 0.009 per perso...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2017-12, Vol.59 (12S), p.S22-S27
Main Authors: Collins, James J., Anteau, Steve, Conner, Patrick R., Cassidy, Laura D., Doney, Brent, Wang, Mei Lin, Kurth, Laura, Carson, Michael, Molenaar, Don, Redlich, Carrie A., Storey, Eileen
Format: Article
Language:English
Subjects:
Adult
Aged
Air Pollutants, Occupational - adverse effects
Air Pollutants, Occupational - analysis
Asthma, Occupational - chemically induced
Asthma, Occupational - epidemiology
Asthma, Occupational - physiopathology
Chemical Industry
Female
Forced Expiratory Volume
Humans
Incidence
Male
Middle Aged
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Odds Ratio
Odorants
Original Article
Time Factors
Toluene 2,4-Diisocyanate - adverse effects
Toluene 2,4-Diisocyanate - analysis
United States - epidemiology
Young Adult
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Summary:OBJECTIVE:This study examines asthma risk in facilities producing toluene diisocyanate (TDI). METHODS:A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures. RESULTS:The incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR] = 2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR = 1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68). CONCLUSIONS:There is evidence that cumulative and peak exposures are associated with TDI-induced asthma.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0000000000000890