Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease

• Published in: Scientific reports 2018-01, Vol.8 (1), p.526-526, Article 526
• Main Authors: Sandri, Thaisa Lucas, Lidani, Kárita Cláudia Freitas, Andrade, Fabiana Antunes, Meyer, Christian G., Kremsner, Peter G., de Messias-Reason, Iara J., Velavan, Thirumalaisamy P.
• Format: Article
• Language: English
• Subjects: 45; 45/23; 631/208/514/1948; 631/208/727/2000; 631/208/727/728; 631/250/255/1715; 82/1; Adult; Aged; Asymptomatic; Binding sites; Cardiomyopathy; Case-Control Studies; Chagas disease; Chagas Disease - genetics; Complement receptors; Enzyme-linked immunosorbent assay; Female; Genetic diversity; Genetic variance; Haplotypes; Heart failure; Humanities and Social Sciences; Humans; Immunopathogenesis; Infections; Kinases; Lectins; Linkage Disequilibrium; Male; Middle Aged; multidisciplinary; Opsonization; Parasites; Pathogenesis; Pathogens; Plasma; Plasma levels; Polymorphism, Single Nucleotide; Proteins; Receptors, Complement 3b - genetics; Receptors, Complement 3b - metabolism; Science; Science (multidisciplinary); Trypanosoma cruzi; Vector-borne diseases
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-18937-z

Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Distinct CR1 exon 29 variants have been found associated with CR1 expression levels, increased susceptibility and pathophysiology of several diseases. In this study, CR1 plasma levels were assessed by ELISA and CR1 variants in exon 29 by sequencing in a Brazilian cohort of 232 chronic CD patients and 104 healthy controls. CR1 levels were significantly decreased in CD patients compared to controls (p