Association of PHD3 and HIF2α gene expression with clinicopathological characteristics in human hepatocellular carcinoma

Egl-9 family hypoxia-inducible factor (HIF)3/prolyl hydroxylase 3 (EGLN3/PHD3) serves a role in the progression and prognosis of cancer. PHD3 is able to induce apoptosis in HepG2 cells. In the present study, the protein levels of PHD3 and HIF2α were analyzed by western blot analysis and immunohistoc...

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Bibliographic Details
Published in:Oncology letters 2018-01, Vol.15 (1), p.545-551
Main Authors: Jiang, Liang, Liu, Qiu-Long, Liang, Qi-Lian, Zhang, Hui-Jie, Ou, Wen-Ting, Yuan, Gao-Le
Format: Article
Language:English
Subjects:
Apoptosis
Biotechnology
Blood clots
Females
Gene expression
Hypoxia
Liver cancer
Medical prognosis
Metastasis
Oncology
Polymerase chain reaction
Protein expression
Proteins
Studies
Veins & arteries
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Summary:Egl-9 family hypoxia-inducible factor (HIF)3/prolyl hydroxylase 3 (EGLN3/PHD3) serves a role in the progression and prognosis of cancer. PHD3 is able to induce apoptosis in HepG2 cells. In the present study, the protein levels of PHD3 and HIF2α were analyzed by western blot analysis and immunohistochemistry in 84 paired hepatocellular carcinoma (HCC) tissues and adjacent non-tumor liver tissues. The mRNA levels of PHD3 and HIF2α were analyzed by reverse transcription-quantitative polymerase chain reaction. PHD3 was overexpressed in HCC tissues compared with adjacent liver tissues (mRNA expression: P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7302