Cardiovascular disease risk factors and oxidative stress among premenopausal women

• Published in: Free radical biology & medicine 2018-02, Vol.115, p.246-251
• Main Authors: Anderson, Chelsea, Milne, Ginger L., Park, Yong-Moon Mark, Sandler, Dale P., Nichols, Hazel B.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers - metabolism; Biometry; Blood Pressure; Body mass index; Cardiovascular disease; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - metabolism; Cohort Studies; Cross-Sectional Studies; Dinoprost - analogs & derivatives; Dinoprost - metabolism; F2-isoprostanes; F2-Isoprostanes - metabolism; Female; Follow-Up Studies; Humans; Hypertension; Middle Aged; Oxidative Stress; Predictive Value of Tests; Premenopause; Prognosis; Risk Factors; United States - epidemiology
• ISSN: 0891-5849; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2017.12.006

Oxidative stress is one hypothesized mechanism linking anthropometric, behavioral, and medical risk factors with cardiovascular disease (CVD). We evaluated cross-sectional associations between CVD risk factors and biomarkers of oxidative stress, and investigated these biomarkers as predictors of incident diabetes and hypertension among premenopausal women. F2-isoprostane (F2-IsoP) and metabolite (15-F2t-IsoP-M), reliable biomarkers of oxidative stress, were measured in urine samples collected at enrollment from 897 premenopausal women (ages 35–54) enrolled in the Sister Study cohort without a CVD history. Blood pressure, waist circumference, and body mass index (BMI) were measured at enrollment by trained study personnel. Diabetes and cigarette smoking were self-reported via enrollment questionnaires. Over a maximum follow-up of 11.5 years, participants self-reported incident diabetes and hypertension diagnoses on mailed questionnaires. In cross-sectional analyses, both F2-IsoP and 15-F2t-IsoP-M were positively associated with BMI, waist circumference, diastolic blood pressure, and current smoking. F2-IsoP was elevated among those with diabetes, and 15-F2t-IsoP-M increased with higher systolic blood pressure. Prospective analyses suggested an increased hypertension risk among those with elevated 15-F2t-IsoP-M (highest vs. lowest quartile: hazard ratio=2.34; 95% CI: 1.20–4.56). Our results suggest that urinary F2-IsoP and 15-F2t-IsoP-M are positively associated with adiposity measures, blood pressure, and cigarette smoking. Further investigation is warranted to evaluate 15-F2t-IsoP-M as a predictor of hypertension. [Display omitted] •Oxidative stress may be a mechanistic link between key risk factors and CVD.•F2-isoprostanes (F2-IsoP) were positively associated with blood pressure measures.•Higher F2-IsoP was also associated with adiposity, diabetes, and current smoking.•Elevated F2-isoprostane metabolite in urine may predict incident hypertension.