Computer aided epitope design as a peptide vaccine component against Lassa virus

Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and deve...

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Bibliographic Details
Published in:Bioinformation 2017-01, Vol.13 (12), p.417-429
Main Authors: Faisal, Ar-Rafi Md, Imtiaz, Syed Hassan, Zerin, Tasnim, Rahman, Tania, Shekhar, Hossain Uddin
Format: Article
Language:English
Subjects:
Hypothesis
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Summary:Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and develop viable vaccine components against the virus. We used the Lassa virus envelope glyco-proteins as a vaccine target to identify linear peptides as potential epitopes with immunogenic properties by computer aided epitope prediction tools. We report a T-cell epitope 'LLGTFTWTL' and a B-cell epitope 'AELKCFGNTAVAKCNE' with predicted potential immunogenicity for further in vivo and in vitro consideration.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630013417