Relationships between lymphocyte counts and treatment-related toxicities and clinical responses in patients with solid tumors treated with PD-1 checkpoint inhibitors

The relationships between absolute lymphocyte counts (ALC), drug- related toxicities, and clinical responses remain unclear in cancer patients treated with PD-1 (programmed cell death 1) inhibitors. We performed a retrospective review of 167 adult solid tumor patients treated with nivolumab or pembr...

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Bibliographic Details
Published in:Oncotarget 2017-12, Vol.8 (69), p.114268-114280
Main Authors: Diehl, Adam, Yarchoan, Mark, Hopkins, Alex, Jaffee, Elizabeth, Grossman, Stuart A
Format: Article
Language:English
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Research Paper
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Summary:The relationships between absolute lymphocyte counts (ALC), drug- related toxicities, and clinical responses remain unclear in cancer patients treated with PD-1 (programmed cell death 1) inhibitors. We performed a retrospective review of 167 adult solid tumor patients treated with nivolumab or pembrolizumab at a single institution between January 2015 and November 2016. Patients with an ALC >2000 at baseline had an increased risk of irAE (OR 1.996, p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.23217