DNA methylation alterations in the genome of a toddler with cri‐du‐chat syndrome

Key Clinical Message This manuscript reports on genomewide epigenetic alterations in cri‐du‐chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new...

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Bibliographic Details
Published in:Clinical case reports 2018-01, Vol.6 (1), p.14-17
Main Authors: Naumova, Oxana Y., Rychkov, Sergey Y., Kuznetzova, Tatyana V., Odintsova, Veronika V., Kornilov, Sergey A., Grigorenko, Elena L.
Format: Article
Language:English
Subjects:
Case Report
Case Reports
case study
cri‐du‐chat syndrome
Deoxyribonucleic acid
DNA
DNA methylation
Genetic disorders
Illumina Infinium Human Methylation450
Toddlers
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Summary:Key Clinical Message This manuscript reports on genomewide epigenetic alterations in cri‐du‐chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new therapeutic interventions for reducing the severity of the disease. This manuscript reports on genomewide epigenetic alterations in cri‐du‐chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new therapeutic interventions for reducing the severity of the disease.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.1274