Critical Shear Stress is Associated with Diabetic Kidney Disease in Patients with Type 2 Diabetes

Critical shear stress (CSS, mPa) is an index of red blood cell (RBC) aggregability, defined as the minimal shear stress required to disperse RBC aggregates. This study aimed to investigate the association between CSS and the risk of diabetic kidney disease (DKD). A total of 421 (mean age, 58.1 ± 11....

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Bibliographic Details
Published in:Scientific reports 2018-01, Vol.8 (1), p.908-7, Article 908
Main Authors: Chung, Seung Min, Oh, Jung Hyun, Moon, Jun Sung, Kim, Yu Kyung, Yoon, Ji Sung, Won, Kyu Chang, Lee, Hyoung Woo
Format: Article
Language:English
Subjects:
639/166/985
692/163/2743/137/138
Albuminuria - urine
Creatinine
Creatinine - urine
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - pathology
Diabetes Mellitus, Type 2 - urine
Diabetic Nephropathies - etiology
Diabetic Nephropathies - pathology
Diabetic Nephropathies - urine
Diabetic nephropathy
Erythrocyte Aggregation - physiology
Erythrocytes
Female
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Hemoglobin
Hemorheology - physiology
Humanities and Social Sciences
Humans
Hypertension
Kidney diseases
Kidneys
Male
Microfluidics
Middle Aged
multidisciplinary
Retrospective Studies
Science
Science (multidisciplinary)
Shear stress
Stress, Mechanical
Urine
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Summary:Critical shear stress (CSS, mPa) is an index of red blood cell (RBC) aggregability, defined as the minimal shear stress required to disperse RBC aggregates. This study aimed to investigate the association between CSS and the risk of diabetic kidney disease (DKD). A total of 421 (mean age, 58.1 ± 11.5 years; male, 250) individuals with T2DM were enrolled and divided into three groups according to CSS level. CSS was measured using a transient microfluidic technique. DKD was defined as a glomerular filtration rate (GFR)
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-19274-5