MicroRNAs and Presbycusis

Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes....

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Bibliographic Details
Published in:Aging and disease 2018-02, Vol.9 (1), p.133-142
Main Authors: Hu, Weiming, Wu, Junwu, Jiang, Wenjing, Tang, Jianguo
Format: Article
Language:English
Subjects:
Aging (Biology)
Care and treatment
Gene mutation
MicroRNA
Presbycusis
Review
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Summary:Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes. It has been identified that various miRNAs are up- or down-regulated during mammalian aging processes in tissue-specific manners. Most miRNAs bind to specific sites on their target messenger-RNAs (mRNAs) and decrease their expression. Germline mutation may lead to dysregulation of potential miRNAs expression, causing progressive hair cell degeneration and age-related hearing loss. Therapeutic innovations could emerge from a better understanding of diverse function of miRNAs in presbycusis. This review summarizes the relationship between miRNAs and presbycusis, and presents novel miRNAs-targeted strategies against presbycusis.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2017.0119