Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this pept...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2018-01, Vol.38 (1), p.7-12
Main Authors: Brimijoin, Stephen, Tye, Susannah
Format: Article
Language:English
Subjects:
Anxiety
Biomedical and Life Sciences
Biomedicine
Cell Biology
Ghrelin
Neurobiology
Neurosciences
Review Paper
Wounds
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Summary:In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-017-0523-z