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Evidence of directional and stabilizing selection in contemporary humans
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of lin...
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Published in: | Proceedings of the National Academy of Sciences - PNAS 2018-01, Vol.115 (1), p.151-156 |
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container_title | Proceedings of the National Academy of Sciences - PNAS |
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creator | Sanjak, Jaleal S. Sidorenko, Julia Robinson, Matthew R. Thornton, Kevin R. Visscher, Peter M. |
description | Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species. |
doi_str_mv | 10.1073/pnas.1707227114 |
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subjects | Biological Evolution Biological Sciences Evolution Female Genetics Humans Male Middle Aged Models, Genetic Molecules Natural selection Phenotype Selection, Genetic United Kingdom |
title | Evidence of directional and stabilizing selection in contemporary humans |
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