Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AK...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget 2017-12, Vol.8 (70), p.115345-115359
Main Authors: Yang, Yanping, Zhao, Jieqiong, Zhang, Juan, Lei, Yonghong, Yuan, Fang, Liu, Lu, Gao, Haibo, Guo, Hua, Niu, Xiaolin, Chen, Ruirui, Fu, Xiaobing, Han, Yan, Han, Hua, Chan, Tung, Zhao, Lianyou, Wang, Haichang, Zheng, Qiangsun, Li, Xue
Format: Article
Language:English
Subjects:
Research Paper
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c308t-cbb149212cb0b8af8e4dbcf739ad6f4497e04861ddce62269c03580d533565f03
container_end_page 115359
container_issue 70
container_start_page 115345
container_title Oncotarget
container_volume 8
creator Yang, Yanping
Zhao, Jieqiong
Zhang, Juan
Lei, Yonghong
Yuan, Fang
Liu, Lu
Gao, Haibo
Guo, Hua
Niu, Xiaolin
Chen, Ruirui
Fu, Xiaobing
Han, Yan
Han, Hua
Chan, Tung
Zhao, Lianyou
Wang, Haichang
Zheng, Qiangsun
Li, Xue
description The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.
doi_str_mv 10.18632/oncotarget.23263
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5777776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1993007802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c308t-cbb149212cb0b8af8e4dbcf739ad6f4497e04861ddce62269c03580d533565f03</originalsourceid><addsrcrecordid>eNpVUclOwzAQtRAIEPQDuCAfubT1kjj2BalUbCoCxHLgZDmOs6AkDnZSxN9jaCkwsjSjmTdvZvwAOMJogjmjZGpbbXvlCtNPCCWMboF9LCIxJnFMt__Ee2Dk_SsKFkcJJ2IX7BFBOcUs2gcvD6YYatVXtoU2h43SznalKgxsqsKt8lV4XpemqTRs7OANLI1yvYfLSkHVwtniiUxvz2Z4-ni_wLBTffmuPg7BTq5qb0ZrfwCeL86f5lfjm7vL6_nsZqwp4v1YpymOBMFEpyjlKucmylKdJ1SojOVRJBKDIs5wlmnDCGFCIxpzlMWUxizOET0ApyvebkgbE1Bt71QtO1c1yn1Iqyr5v9JWpSzsUsbJl7FAcLImcPZtML6XTTjX1LVqTbhWYiEoQglHJEDxChp-yXtn8s0YjOS3KvJXFfmtSug5_rvfpuNHA_oJsSGLmQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993007802</pqid></control><display><type>article</type><title>Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway</title><source>PMC (PubMed Central)</source><creator>Yang, Yanping ; Zhao, Jieqiong ; Zhang, Juan ; Lei, Yonghong ; Yuan, Fang ; Liu, Lu ; Gao, Haibo ; Guo, Hua ; Niu, Xiaolin ; Chen, Ruirui ; Fu, Xiaobing ; Han, Yan ; Han, Hua ; Chan, Tung ; Zhao, Lianyou ; Wang, Haichang ; Zheng, Qiangsun ; Li, Xue</creator><creatorcontrib>Yang, Yanping ; Zhao, Jieqiong ; Zhang, Juan ; Lei, Yonghong ; Yuan, Fang ; Liu, Lu ; Gao, Haibo ; Guo, Hua ; Niu, Xiaolin ; Chen, Ruirui ; Fu, Xiaobing ; Han, Yan ; Han, Hua ; Chan, Tung ; Zhao, Lianyou ; Wang, Haichang ; Zheng, Qiangsun ; Li, Xue</creatorcontrib><description>The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.23263</identifier><identifier>PMID: 29383164</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2017-12, Vol.8 (70), p.115345-115359</ispartof><rights>Copyright: © 2017 Yang et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c308t-cbb149212cb0b8af8e4dbcf739ad6f4497e04861ddce62269c03580d533565f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777776/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777776/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29383164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yanping</creatorcontrib><creatorcontrib>Zhao, Jieqiong</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Lei, Yonghong</creatorcontrib><creatorcontrib>Yuan, Fang</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Gao, Haibo</creatorcontrib><creatorcontrib>Guo, Hua</creatorcontrib><creatorcontrib>Niu, Xiaolin</creatorcontrib><creatorcontrib>Chen, Ruirui</creatorcontrib><creatorcontrib>Fu, Xiaobing</creatorcontrib><creatorcontrib>Han, Yan</creatorcontrib><creatorcontrib>Han, Hua</creatorcontrib><creatorcontrib>Chan, Tung</creatorcontrib><creatorcontrib>Zhao, Lianyou</creatorcontrib><creatorcontrib>Wang, Haichang</creatorcontrib><creatorcontrib>Zheng, Qiangsun</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><title>Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUclOwzAQtRAIEPQDuCAfubT1kjj2BalUbCoCxHLgZDmOs6AkDnZSxN9jaCkwsjSjmTdvZvwAOMJogjmjZGpbbXvlCtNPCCWMboF9LCIxJnFMt__Ee2Dk_SsKFkcJJ2IX7BFBOcUs2gcvD6YYatVXtoU2h43SznalKgxsqsKt8lV4XpemqTRs7OANLI1yvYfLSkHVwtniiUxvz2Z4-ni_wLBTffmuPg7BTq5qb0ZrfwCeL86f5lfjm7vL6_nsZqwp4v1YpymOBMFEpyjlKucmylKdJ1SojOVRJBKDIs5wlmnDCGFCIxpzlMWUxizOET0ApyvebkgbE1Bt71QtO1c1yn1Iqyr5v9JWpSzsUsbJl7FAcLImcPZtML6XTTjX1LVqTbhWYiEoQglHJEDxChp-yXtn8s0YjOS3KvJXFfmtSug5_rvfpuNHA_oJsSGLmQ</recordid><startdate>20171229</startdate><enddate>20171229</enddate><creator>Yang, Yanping</creator><creator>Zhao, Jieqiong</creator><creator>Zhang, Juan</creator><creator>Lei, Yonghong</creator><creator>Yuan, Fang</creator><creator>Liu, Lu</creator><creator>Gao, Haibo</creator><creator>Guo, Hua</creator><creator>Niu, Xiaolin</creator><creator>Chen, Ruirui</creator><creator>Fu, Xiaobing</creator><creator>Han, Yan</creator><creator>Han, Hua</creator><creator>Chan, Tung</creator><creator>Zhao, Lianyou</creator><creator>Wang, Haichang</creator><creator>Zheng, Qiangsun</creator><creator>Li, Xue</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171229</creationdate><title>Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway</title><author>Yang, Yanping ; Zhao, Jieqiong ; Zhang, Juan ; Lei, Yonghong ; Yuan, Fang ; Liu, Lu ; Gao, Haibo ; Guo, Hua ; Niu, Xiaolin ; Chen, Ruirui ; Fu, Xiaobing ; Han, Yan ; Han, Hua ; Chan, Tung ; Zhao, Lianyou ; Wang, Haichang ; Zheng, Qiangsun ; Li, Xue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-cbb149212cb0b8af8e4dbcf739ad6f4497e04861ddce62269c03580d533565f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yanping</creatorcontrib><creatorcontrib>Zhao, Jieqiong</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Lei, Yonghong</creatorcontrib><creatorcontrib>Yuan, Fang</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Gao, Haibo</creatorcontrib><creatorcontrib>Guo, Hua</creatorcontrib><creatorcontrib>Niu, Xiaolin</creatorcontrib><creatorcontrib>Chen, Ruirui</creatorcontrib><creatorcontrib>Fu, Xiaobing</creatorcontrib><creatorcontrib>Han, Yan</creatorcontrib><creatorcontrib>Han, Hua</creatorcontrib><creatorcontrib>Chan, Tung</creatorcontrib><creatorcontrib>Zhao, Lianyou</creatorcontrib><creatorcontrib>Wang, Haichang</creatorcontrib><creatorcontrib>Zheng, Qiangsun</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yanping</au><au>Zhao, Jieqiong</au><au>Zhang, Juan</au><au>Lei, Yonghong</au><au>Yuan, Fang</au><au>Liu, Lu</au><au>Gao, Haibo</au><au>Guo, Hua</au><au>Niu, Xiaolin</au><au>Chen, Ruirui</au><au>Fu, Xiaobing</au><au>Han, Yan</au><au>Han, Hua</au><au>Chan, Tung</au><au>Zhao, Lianyou</au><au>Wang, Haichang</au><au>Zheng, Qiangsun</au><au>Li, Xue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-12-29</date><risdate>2017</risdate><volume>8</volume><issue>70</issue><spage>115345</spage><epage>115359</epage><pages>115345-115359</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>29383164</pmid><doi>10.18632/oncotarget.23263</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1949-2553
ispartof Oncotarget, 2017-12, Vol.8 (70), p.115345-115359
issn 1949-2553
1949-2553
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5777776
source PMC (PubMed Central)
subjects Research Paper
title Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A36%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20macrophage%20migration%20in%20ischemic%20mouse%20hearts%20via%20an%20AKT2/NBA1/SPK1%20pathway&rft.jtitle=Oncotarget&rft.au=Yang,%20Yanping&rft.date=2017-12-29&rft.volume=8&rft.issue=70&rft.spage=115345&rft.epage=115359&rft.pages=115345-115359&rft.issn=1949-2553&rft.eissn=1949-2553&rft_id=info:doi/10.18632/oncotarget.23263&rft_dat=%3Cproquest_pubme%3E1993007802%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c308t-cbb149212cb0b8af8e4dbcf739ad6f4497e04861ddce62269c03580d533565f03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1993007802&rft_id=info:pmid/29383164&rfr_iscdi=true