Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

Background Optical coherence tomography (OCT) allows tissue histologic‐like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient inf...

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Bibliographic Details
Published in:Head & neck 2014-09, Vol.36 (9), p.1329-1334
Main Authors: Conti de Freitas, Luiz C., Phelan, Eimear, Liu, Linbo, Gardecki, Joseph, Namati, Eman, Warger, Willian C., Tearney, Guillermo J., Randolph, Gregory W.
Format: Article
Language:English
Subjects:
Adipose Tissue - pathology
Adult
Female
Frozen Sections
Humans
hyperparathyroidism
Lymph Nodes - pathology
Male
Middle Aged
Muscles - pathology
Neck Dissection
parathyroid adenoma
Parathyroid Neoplasms - pathology
Parathyroid Neoplasms - surgery
Parathyroidectomy
Pilot Projects
thyroid cancer
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Tomography, Optical Coherence
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Summary:Background Optical coherence tomography (OCT) allows tissue histologic‐like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Methods Normal tissues were obtained from patients undergoing surgical treatment. Two new‐generation OCT systems, including optical frequency domain imaging (OFDI) and μOCT, were compared to representative hematoxylin‐eosin histology. Results Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic‐like microscopic characteristics sufficient for tissue type identification was realized using both systems for all tissue types examined. Conclusion This pilot study demonstrated that new‐generation OCT systems are capable of recognizing and differentiating neck tissues encountered during thyroid and parathyroid surgeries. Further advances in OCT miniaturization and development of sterile intraoperative probe formats may allow OCT to offer an intraoperative “optical biopsy” without fixation, staining, or tissue resection. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1329–1334, 2014
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23452