Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging

A number of studies have demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be used to evaluate microvessel density (MVD), and may quantitatively reflect tumor angiogenesis. To investigate the dynamics, including angiogenesis and tumor cellularity, of rabbit VX2 tum...

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Bibliographic Details
Published in:Oncology letters 2018-03, Vol.15 (3), p.2978-2984
Main Authors: Li, Haixia, Yu, Lijuan, Wang, Wenzhi, Wang, Lingling, Zheng, Xiulan, Dai, Shaochun, Sun, Yanqin
Format: Article
Language:English
Subjects:
Angiogenesis
Cancer research
Carcinogenesis
Cell growth
Contrast media
Gangrene
Health aspects
Laboratory animals
Magnetic resonance imaging
Medical imaging
Methods
Morphology
Neovascularization
NMR
Nuclear magnetic resonance
Observations
Oncology
Permeability
Physiology
Rabbits
Software
Tumors
Vascular endothelial growth factor
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Summary:A number of studies have demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be used to evaluate microvessel density (MVD), and may quantitatively reflect tumor angiogenesis. To investigate the dynamics, including angiogenesis and tumor cellularity, of rabbit VX2 tumors during the 4 weeks following tumor implantation, the present study used DCE-MRI combined with diffusion-weighted imaging (DWI) to scan the tumors at 3 days, and then at 1, 2, 3 and 4-week intervals, following tumor implantation. The dynamics, volume transfer coefficient (K ) and apparent diffusion coefficient (ADC) of the tumor parenchyma were analyzed. Furthermore, the associations between K and MVD at 4 weeks after tumor implantation were analyzed. Tumor K was positively correlated with MVD at 4 weeks (r=0.674, P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7657