Roles of toll-like receptors: From inflammation to lung cancer progression

Lung cancer is among the most common malignant tumors worldwide, and is characterized by a low survival rate compared with other cancers. Toll-like receptors (TLRs) are highly conserved in evolution and widely expressed on immune cells, where they serve an important role in the innate immune system...

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Bibliographic Details
Published in:Biomedical reports 2018-02, Vol.8 (2), p.126-132
Main Authors: Gu, Jinjing, Liu, Yi, Xie, Bin, Ye, Pingping, Huang, Jiefan, Lu, Zhe
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Cancer
Cancer therapies
Chemotherapy
Cytokines
Development and progression
DNA methylation
Epigenetics
Gene expression
Immune response
Immune system
Infections
Inflammation
Innate immunity
Kinases
Lung cancer
Medical prognosis
Metastasis
Mortality
Proteins
Receptors
Respiratory system agents
Review
Signal transduction
Signaling
Stem cell transplantation
Stem cells
Toll-like receptors
Tuberculosis
Tumor cells
Tumor necrosis factor-TNF
Tumorigenesis
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Summary:Lung cancer is among the most common malignant tumors worldwide, and is characterized by a low survival rate compared with other cancers. Toll-like receptors (TLRs) are highly conserved in evolution and widely expressed on immune cells, where they serve an important role in the innate immune system by evoking inflammatory responses. Evasion of immune destruction is an important hallmark in the development of cancer. There is an established association between chronic inflammation and cancer, with TLRs serving important roles in the immune response against tumor cells. Recently, TLRs have been identified on tumor cells, where their activation may orchestrate the downstream signaling pathways that serve crucial functions in tumorigenesis and tumor progression. The present review summarizes the roles of TLRs as sensors on lung cancer cells that regulate lung cancer progression with regard to cell growth and invasion, angiogenesis and cancer stem cell behavior. This aimed to provide theoretical support for the development of therapies that target TLR signaling pathways for the treatment of lung cancer.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2017.1034