A systematic review and meta-analysis: Association between MGMT hypermethylation and the clinicopathological characteristics of non-small-cell lung carcinoma

The relationship between O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and clinicopathological characteristics of non-small-cell lung carcinoma (NSCLC) has remained controversial and unclear. Therefore, in this study we have undertaken a systematic review and meta-analysis of r...

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Bibliographic Details
Published in:Scientific reports 2018-01, Vol.8 (1), p.1439-11, Article 1439
Main Authors: Chen, Lin, Wang, Yong, Liu, Fen, Xu, Liyao, Peng, Feifei, Zhao, Ning, Fu, Biqi, Zhu, Zijie, Shi, Yu, Liu, Jiansheng, Wu, Renrui, Wang, Chen, Yao, Shengmin, Li, Yong
Format: Article
Language:English
Subjects:
38/39
631/67/1612/1350
631/67/395
DNA methylation
DNA methyltransferase
Humanities and Social Sciences
Lung cancer
Lung carcinoma
Meta-analysis
Methylguanine
Minority & ethnic groups
multidisciplinary
Non-small cell lung carcinoma
O6-methylguanine-DNA methyltransferase
Science
Science (multidisciplinary)
Smoking
Studies
Systematic review
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Summary:The relationship between O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and clinicopathological characteristics of non-small-cell lung carcinoma (NSCLC) has remained controversial and unclear. Therefore, in this study we have undertaken a systematic review and meta-analysis of relevant studies to quantitatively investigate this association. We identified 30 eligible studies investigating 2714 NSCLC patients. The relationship between MGMT hypermethylation and NSCLC was identified based on 20 studies, including 1539 NSCLC patient tissue and 1052 normal and adjacent tissue samples (OR = 4.60, 95% CI = 3.46~6.11, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-19949-z