Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction

Objective To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). Methods A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2018-02, Vol.26 (2), p.284-290
Main Authors: Mikhalkova, Deana, Holman, Sujata R., Jiang, Hui, Saghir, Mohammed, Novak, Eric, Coggan, Andrew R., O'Connor, Robert, Bashir, Adil, Jamal, Ali, Ory, Daniel S., Schaffer, Jean E., Eagon, J. Christopher, Peterson, Linda R.
Format: Article
Language:English
Subjects:
Bariatric Surgery - adverse effects
Cardiovascular disease
Ejection fraction
Family medical history
Female
Gastrointestinal surgery
Heart - physiopathology
Heart failure
Heart Failure - etiology
Heart Failure - pathology
Heart surgery
Humans
Hypertension
Lipids
Male
Metabolism
Middle Aged
Mortality
Obesity
Obesity - complications
Obesity - pathology
Plasma
Questionnaires
Stroke Volume - physiology
Studies
Weight control
Womens health
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Summary:Objective To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). Methods A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22). Results After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.22038