Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance

BACKGROUND The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL AND METHODS Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used...

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Bibliographic Details
Published in:Medical science monitor 2018-01, Vol.24, p.348-355
Main Authors: Wu, Ping-Li, He, Yi-Fu, Yao, Han-Hui, Hu, Bing
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lab/In Vitro Research
Male
Matrilin Proteins - biosynthesis
Matrilin Proteins - genetics
Middle Aged
Prognosis
Proteomics
Retrospective Studies
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
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Summary:BACKGROUND The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL AND METHODS Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expression and prognostic value of MATN3 mRNA in GAC patients. Seventy-six GAC patients had GAC tissue samples and paired adjacent normal tissue samples collected retrospectively to examine the MATN3 protein expression level by immunohistochemical staining. Furthermore, Kaplan-Meier univariate and Cox multivariate analyses were used to verify the correlation between MATN3 expression and clinicopathological parameters of GAC patients and the prognostic significance of MATN3. RESULTS The GEO and TCGA data predicted that MATN3 mRNA levels were significantly higher in GAC tissue compared to normal tissue (all p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.908447