The Hypoxia-Adenosine Link during Intestinal Inflammation

Intestinal inflammation is a key element in inflammatory bowel disease and is related to a combination of factors, including genetics, mucosal barrier dysfunction, bacteria translocation, deleterious host-microbe interactions, and dysregulated immune responses. Over the past decade, it has been appr...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2018-02, Vol.200 (3), p.897-907
Main Authors: Bowser, Jessica L, Phan, Luan H, Eltzschig, Holger K
Format: Article
Language:English
Subjects:
Adenosine
Adenosine - metabolism
Animals
Anti-inflammatory agents
Cell Hypoxia - physiology
Colon
Colon cancer
Colonic Neoplasms - pathology
Colorectal cancer
Epithelial Cells - microbiology
Epithelial Cells - pathology
Genetics
Humans
Hypoxia
Immune response
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - pathology
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Intestinal Mucosa - pathology
Intestine
Ischemia
Lesions
Mice
Mucosa
Reperfusion
Reperfusion Injury - pathology
Small intestine
Tight Junctions - pathology
Translocation
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Summary:Intestinal inflammation is a key element in inflammatory bowel disease and is related to a combination of factors, including genetics, mucosal barrier dysfunction, bacteria translocation, deleterious host-microbe interactions, and dysregulated immune responses. Over the past decade, it has been appreciated that these inflammatory lesions are associated with profound tissue hypoxia. Interestingly, an endogenous adaptive response under the control of hypoxia signaling is enhancement in adenosine signaling, which impacts these different endpoints, including promoting barrier function and encouraging anti-inflammatory activity. In this review, we discuss the hypoxia-adenosine link in inflammatory bowel disease, intestinal ischemia/reperfusion injury, and colon cancer. In addition, we provide a summary of clinical implications of hypoxia and adenosine signaling in intestinal inflammation and disease.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1701414