Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss

Angiopoietin-like 2 (ANGPTL2) is an inflammatory adipokine linking obesity to insulin resistance. Intermittent fasting, on the other hand, is a lifestyle intervention able to prevent obesity and diabetes but difficult to implement and maintain. Our objectives were to characterize a link between ANGP...

Full description

Saved in:
Bibliographic Details
Published in:Experimental biology and medicine (Maywood, N.J.) N.J.), 2018-01, Vol.243 (1), p.45-49
Main Authors: Martel, Cécile, Pinçon, Anthony, Bélanger, Alexandre Maxime, Luo, Xiaoyan, Gillis, Marc-Antoine, de Montgolfier, Olivia, Thorin-Trescases, Nathalie, Thorin, Éric
Format: Article
Language:English
Subjects:
Brief Communications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiopoietin-like 2 (ANGPTL2) is an inflammatory adipokine linking obesity to insulin resistance. Intermittent fasting, on the other hand, is a lifestyle intervention able to prevent obesity and diabetes but difficult to implement and maintain. Our objectives were to characterize a link between ANGPTL2 and intermittent fasting and to investigate whether the knockdown of ANGPTL2 reproduces the benefits of intermittent fasting on weight gain and insulin responsiveness in knockdown and wild-type littermates mice. Intermittent fasting, access to food ad libitum once every other day, was initiated at the age of three months and maintained for four months. Intermittent fasting decreased by 63% (p 
ISSN:1535-3702
1535-3699
DOI:10.1177/1535370217745505