Use of N-Acetylcysteine in Psychiatric Conditions among Children and Adolescents: A Scoping Review

N-acetylcysteine (NAC) is a well-known antidote for acetaminophen toxicity and is easily available over the counter. It has antioxidant and anti-inflammatory properties and an established tolerance and safety profile. Owing to its neuroprotective effects, its clinical use has recently expanded to in...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2017-11, Vol.9 (11), p.e1888-e1888
Main Authors: Naveed, Sadiq, Amray, Afshan, Waqas, Ahmed, Chaudhary, Amna M, Azeem, Muhammad W
Format: Article
Language:English
Subjects:
Addictive behaviors
Antioxidants
Autism
Behavior disorders
Comorbidity
Deoxyribonucleic acid
DNA
Hair
Marijuana
Obsessive compulsive disorder
Pediatrics
Psychiatry
Psychotropic drugs
Social research
Teenagers
Tourette syndrome
Urine
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Summary:N-acetylcysteine (NAC) is a well-known antidote for acetaminophen toxicity and is easily available over the counter. It has antioxidant and anti-inflammatory properties and an established tolerance and safety profile. Owing to its neuroprotective effects, its clinical use has recently expanded to include the treatment of different psychiatric and non-psychiatric disorders. Although a number of randomized controlled trials have documented the clinical evidence for NAC, there are no reviews that summarize the evidence. The present scoping review summarizes the study designs, the patient characteristics, the evidence and the limitations in randomized controlled trials designed to explore the efficacy of NAC for psychiatric conditions in the pediatric population.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.1888