Combined drug therapeutic strategies for the effective treatment of Triple Negative Breast Cancer

TNBC (Triple Negative Breast Cancer) is a subtype of breast cancer with an aggressive phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic properties like heterogeneity, lack of hormonal receptors and aggressive phenotype leave chemotherapy as a mainstay for th...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience reports 2018-02, Vol.38 (1)
Main Authors: Chalakur-Ramireddy, Naveen K R, Pakala, Suresh B
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Apoptosis
Biomarkers
Breast cancer
Cancer therapies
Cell growth
Chemotherapy
Clinical trials
Combinatorial analysis
DNA repair
Drug delivery
Drugs
Epigenetics
Female
Gene expression
Genotype & phenotype
Heterogeneity
Humans
Immunotherapy
Immunotherapy - trends
Kinases
Medical prognosis
Metabolism
Metastases
Metastasis
Mutation
Neoplasm Metastasis
Pathogenesis
Phenotypes
Proteins
Receptor mechanisms
Review
Stem cells
Triple Negative Breast Neoplasms - drug therapy
Triple Negative Breast Neoplasms - pathology
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:TNBC (Triple Negative Breast Cancer) is a subtype of breast cancer with an aggressive phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic properties like heterogeneity, lack of hormonal receptors and aggressive phenotype leave chemotherapy as a mainstay for the treatment of TNBC. Various studies have demonstrated that chemotherapy alone or therapeutic drugs targeting TNBC pathways, epigenetic mechanisms and immunotherapy alone have not shown significant improvement in TNBC patients. On the other hand, a combination of therapeutic drugs or addition of chemotherapy with therapeutic drugs has shown substantial improvement in results and proven to be an effective strategy for TNBC treatment. This review sheds light on effective combinational drug strategies and current clinical trial status of various combinatorial drugs for the treatment of TNBC.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20171357