Current Advances in Aptamers for Cancer Diagnosis and Therapy

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SE...

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Bibliographic Details
Published in:Cancers 2018-01, Vol.10 (1), p.9
Main Authors: Hori, Shin-Ichiro, Herrera, Alberto, Rossi, John J, Zhou, Jiehua
Format: Article
Language:English
Subjects:
Affinity
Aptamers
Cancer
Cancer therapies
Diagnosis
Ligands
Medical diagnosis
Nucleic acids
Oligonucleotides
Review
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Summary:Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers10010009