Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis

Primary involvement of leptomeninges with melanocytic tumours is rarely seen and its diagnosis is challenging. Here we summarise two cases of primary leptomeningeal melanomatosis presenting as subacute meningitis. Both cases have pleocytosis and high protein on cerebrospinal fluid analysis, and demo...

Full description

Saved in:
Bibliographic Details
Published in:The neuroradiology journal 2018-02, Vol.31 (1), p.42-46
Main Authors: Aslan, Sabina, Gocmen, Rahsan, Acar, Nazire Pınar, Khasiyev, Farid, Gumeler, Ekim, Soylemezoglu, Figen, Tuncer, Aslı, Arsava, Ethem Murat, Topçuoglu, Mehmet Akif, Unal Cevik, Isin
Format: Article
Language:English
Subjects:
Neuroimaging of Neoplasms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary involvement of leptomeninges with melanocytic tumours is rarely seen and its diagnosis is challenging. Here we summarise two cases of primary leptomeningeal melanomatosis presenting as subacute meningitis. Both cases have pleocytosis and high protein on cerebrospinal fluid analysis, and demonstrated atypical cells on cytology. On magnetic resonance imaging, there is diffuse leptomeningal thickening and avid enhancement of intracranial and intraspinal leptomeninges. One of them demonstrates T1 shortening due to magnetic effects of melanin, the other case is amelanotic and shows hypointensity on precontrast T1-weighted images. Both cases can be diagnosed with biopsy. In conclusion, these cases highlight the importance of the correct interpretation of cytological and magnetic resonance imaging findings in patients with atypical findings.
ISSN:1971-4009
2385-1996
DOI:10.1177/1971400917708581