Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW

Plasmodium knowlesi is reported increasingly across Southeast Asia and is the most common cause of malaria in Malaysia. No randomized trials have assessed the comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. A randomized controlled trial was conducted in 3 district hospital...

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Bibliographic Details
Published in:Clinical infectious diseases 2018-01, Vol.66 (2), p.229-236
Main Authors: Grigg, Matthew J, William, Timothy, Barber, Bridget E, Rajahram, Giri S, Menon, Jayaram, Schimann, Emma, Wilkes, Christopher S, Patel, Kaajal, Chandna, Arjun, Price, Ric N, Yeo, Tsin W, Anstey, Nicholas M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
and Commentaries
Anemia
Antimalarials - administration & dosage
Antimalarials - adverse effects
Artemether
Artemether, Lumefantrine Drug Combination - administration & dosage
Artemether, Lumefantrine Drug Combination - adverse effects
Artemisinin
Child
Child, Preschool
Children
Chloroquine
Chloroquine - administration & dosage
Chloroquine - adverse effects
Clinical trials
Confidence intervals
Control methods
Diagnostic systems
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - pathology
Effectiveness
Female
Histidine
Hospitals
Humans
Malaria
Malaria - drug therapy
Malaria - parasitology
Malaysia
Male
Medical treatment
Middle Aged
Motivation
Parasitemia
Patients
Plasmodium knowlesi
Plasmodium knowlesi - isolation & purification
Polymerase chain reaction
Randomization
Treatment Outcome
Vector-borne diseases
Young Adult
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Summary:Plasmodium knowlesi is reported increasingly across Southeast Asia and is the most common cause of malaria in Malaysia. No randomized trials have assessed the comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. A randomized controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria. Participants were included if they weighed >10 kg, had a parasitemia count
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix779