Emerging Insights into Noncanonical Inflammasome Recognition of Microbes

Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-b...

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Bibliographic Details
Published in:Journal of molecular biology 2018-01, Vol.430 (2), p.207-216
Main Authors: Russo, Ashley J., Behl, Bharat, Banerjee, Ishita, Rathinam, Vijay A.K.
Format: Article
Language:English
Subjects:
caspase-11
gasdermin D
inflammasome
LPS
outer-membrane vesicles
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Summary:Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its biological functions. [Display omitted] •Noncanonical inflammasome relies on sensing the cytosolic presence of LPS of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11.•This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its roles in anti-microbial defense.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2017.10.003