Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 4...

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Bibliographic Details
Published in:Internal Medicine 2017/12/15, Vol.56(24), pp.3373-3377
Main Authors: Honda, Fumika, Tsuboi, Hiroto, Toko, Hirofumi, Ohyama, Ayako, Takahashi, Hidenori, Abe, Saori, Yokosawa, Masahiro, Asashima, Hiromitsu, Hagiwara, Shinya, Hirota, Tomoya, Kondo, Yuya, Matsumoto, Isao, Sumida, Takayuki
Format: Article
Language:English
Subjects:
Adult
Biopsy
Case Report
Case reports
Corticoids
Corticosteroids
Dose-Response Relationship, Drug
Drug Therapy, Combination
Etiology
Female
Fever
histiocytic necrotizing lymphadenitis
Histiocytic Necrotizing Lymphadenitis - drug therapy
Humans
Hydroxychloroquine
Hydroxychloroquine - administration & dosage
Hydroxychloroquine - therapeutic use
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - therapeutic use
Internal medicine
Kikuchi-Fujimoto disease
Lymphadenitis
Lymphadenopathy
Prednisolone
Prednisolone - administration & dosage
Prednisolone - therapeutic use
Recurrence
Remission
Tapering
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Description
Summary:Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9205-17