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Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review
Background Many solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be u...
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| Published in: | Pediatric radiology 2018-02, Vol.48 (2), p.241-252 |
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| container_issue | 2 |
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| container_title | Pediatric radiology |
| container_volume | 48 |
| creator | Smets, A. M. Deurloo, E. E. Slager, T. J. E. Stoker, J. Bipat, S. |
| description | Background
Many solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be unconditionally extrapolated to staging of children with malignant solid tumors.
Objective
To conduct a literature review on the sensitivity of WB-MRI for detecting skeletal metastases in children with solid tumors.
Materials and methods
Searches in MEDLINE and EMBASE databases up to 15 May 2017 were performed to identify studies on the diagnostic value of WB-MRI. Inclusion criteria were children and adolescents (age |
| doi_str_mv | 10.1007/s00247-017-4013-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5790860</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1966441167</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-291eb34ff43c93eca38c19fad72bc2803c55fc51893ff534089f3a4c1738f9f63</originalsourceid><addsrcrecordid>eNp1kcGKFDEQhoMo7rj6AF4k4MVLNOmkp5OLIIu7CgteFI8hk67MZE0nY5LeZR7E9zVDj8sqCCGB1Fd_1c-P0EtG3zJKh3eF0k4MhLKBCMo4kY_QigneEaaUfIxWlFNGqBDqDD0r5YZSynvGn6KzTrGeMaZW6Nf3XQpANmk84MlsI1RvcYaSookWsG9_Pm6xSxmPUMFWnyJODpcfEKCagKd2l3agYB-x3fkwZojYxBEf0txa95D2AfCdrzu8z00wH3BJwY-4zlPKBRNcDqXCZJbRtx7unqMnzoQCL07vOfp2-fHrxSdy_eXq88WHa2LFQCtpNmDDhXOCW8XBGi4tU86MQ7exnaTc9r2zPZOKO9dzQaVy3AjLBi6dcmt-jt4vuvt5M8FoIdZsgj6tqZPx-u9K9Du9Tbe6HxSVa9oE3pwEcvo5Q6l68sVCCCZCmotmar0WgrH10NDX_6A3ac6x2TtS_cC5VKJRbKFsTqVkcPfLMKqPoesldN1C18fQtWw9rx66uO_4k3IDugUorRS3kB-M_q_qb10Lu2Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1965733894</pqid></control><display><type>article</type><title>Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Smets, A. M. ; Deurloo, E. E. ; Slager, T. J. E. ; Stoker, J. ; Bipat, S.</creator><creatorcontrib>Smets, A. M. ; Deurloo, E. E. ; Slager, T. J. E. ; Stoker, J. ; Bipat, S.</creatorcontrib><description>Background
Many solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be unconditionally extrapolated to staging of children with malignant solid tumors.
Objective
To conduct a literature review on the sensitivity of WB-MRI for detecting skeletal metastases in children with solid tumors.
Materials and methods
Searches in MEDLINE and EMBASE databases up to 15 May 2017 were performed to identify studies on the diagnostic value of WB-MRI. Inclusion criteria were children and adolescents (age <21 years) with a primary solid tumor who were evaluated for skeletal metastases by WB-MRI and compared to any type of reference standard. The number of included patients had to be at least five and data on true positives, true negatives, false-positives and false-negatives had to be extractable.
Results
Five studies including 132 patients (96 patients with solid tumors) were eligible. Patient groups and used reference tests were heterogeneous, producing unclear or high risk of bias. Sensitivity of WB-MRI ranged between 82% and 100%. The positive predictive value of WB-MRI was variable among the studies and influenced by the used reference standard.
Conclusion
Although WB-MRI may seem a promising radiation-free technique for the detection of skeletal metastases in children with solid tumors, published studies are small and too heterogeneous to provide conclusive evidence that WB-MRI can be an alternative to currently used imaging techniques.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-017-4013-8</identifier><identifier>PMID: 29151119</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescents ; Adults ; Biocompatibility ; Biomedical materials ; Children ; Diagnostic systems ; Imaging ; Imaging techniques ; Literature reviews ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Neoplasms ; Neuroradiology ; NMR ; Nuclear magnetic resonance ; Nuclear Medicine ; Oncology ; Original ; Original Article ; Patients ; Pediatrics ; Radiation ; Radiology ; Resonance ; Sensitivity ; Solid tumors ; Tumors ; Ultrasound ; Young adults</subject><ispartof>Pediatric radiology, 2018-02, Vol.48 (2), p.241-252</ispartof><rights>The Author(s) 2017</rights><rights>Pediatric Radiology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-291eb34ff43c93eca38c19fad72bc2803c55fc51893ff534089f3a4c1738f9f63</citedby><cites>FETCH-LOGICAL-c470t-291eb34ff43c93eca38c19fad72bc2803c55fc51893ff534089f3a4c1738f9f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29151119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smets, A. M.</creatorcontrib><creatorcontrib>Deurloo, E. E.</creatorcontrib><creatorcontrib>Slager, T. J. E.</creatorcontrib><creatorcontrib>Stoker, J.</creatorcontrib><creatorcontrib>Bipat, S.</creatorcontrib><title>Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Background
Many solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be unconditionally extrapolated to staging of children with malignant solid tumors.
Objective
To conduct a literature review on the sensitivity of WB-MRI for detecting skeletal metastases in children with solid tumors.
Materials and methods
Searches in MEDLINE and EMBASE databases up to 15 May 2017 were performed to identify studies on the diagnostic value of WB-MRI. Inclusion criteria were children and adolescents (age <21 years) with a primary solid tumor who were evaluated for skeletal metastases by WB-MRI and compared to any type of reference standard. The number of included patients had to be at least five and data on true positives, true negatives, false-positives and false-negatives had to be extractable.
Results
Five studies including 132 patients (96 patients with solid tumors) were eligible. Patient groups and used reference tests were heterogeneous, producing unclear or high risk of bias. Sensitivity of WB-MRI ranged between 82% and 100%. The positive predictive value of WB-MRI was variable among the studies and influenced by the used reference standard.
Conclusion
Although WB-MRI may seem a promising radiation-free technique for the detection of skeletal metastases in children with solid tumors, published studies are small and too heterogeneous to provide conclusive evidence that WB-MRI can be an alternative to currently used imaging techniques.</description><subject>Adolescents</subject><subject>Adults</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Children</subject><subject>Diagnostic systems</subject><subject>Imaging</subject><subject>Imaging techniques</subject><subject>Literature reviews</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasms</subject><subject>Neuroradiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Radiation</subject><subject>Radiology</subject><subject>Resonance</subject><subject>Sensitivity</subject><subject>Solid tumors</subject><subject>Tumors</subject><subject>Ultrasound</subject><subject>Young adults</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kcGKFDEQhoMo7rj6AF4k4MVLNOmkp5OLIIu7CgteFI8hk67MZE0nY5LeZR7E9zVDj8sqCCGB1Fd_1c-P0EtG3zJKh3eF0k4MhLKBCMo4kY_QigneEaaUfIxWlFNGqBDqDD0r5YZSynvGn6KzTrGeMaZW6Nf3XQpANmk84MlsI1RvcYaSookWsG9_Pm6xSxmPUMFWnyJODpcfEKCagKd2l3agYB-x3fkwZojYxBEf0txa95D2AfCdrzu8z00wH3BJwY-4zlPKBRNcDqXCZJbRtx7unqMnzoQCL07vOfp2-fHrxSdy_eXq88WHa2LFQCtpNmDDhXOCW8XBGi4tU86MQ7exnaTc9r2zPZOKO9dzQaVy3AjLBi6dcmt-jt4vuvt5M8FoIdZsgj6tqZPx-u9K9Du9Tbe6HxSVa9oE3pwEcvo5Q6l68sVCCCZCmotmar0WgrH10NDX_6A3ac6x2TtS_cC5VKJRbKFsTqVkcPfLMKqPoesldN1C18fQtWw9rx66uO_4k3IDugUorRS3kB-M_q_qb10Lu2Y</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Smets, A. M.</creator><creator>Deurloo, E. E.</creator><creator>Slager, T. J. E.</creator><creator>Stoker, J.</creator><creator>Bipat, S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review</title><author>Smets, A. M. ; Deurloo, E. E. ; Slager, T. J. E. ; Stoker, J. ; Bipat, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-291eb34ff43c93eca38c19fad72bc2803c55fc51893ff534089f3a4c1738f9f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescents</topic><topic>Adults</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Children</topic><topic>Diagnostic systems</topic><topic>Imaging</topic><topic>Imaging techniques</topic><topic>Literature reviews</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neoplasms</topic><topic>Neuroradiology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Radiation</topic><topic>Radiology</topic><topic>Resonance</topic><topic>Sensitivity</topic><topic>Solid tumors</topic><topic>Tumors</topic><topic>Ultrasound</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smets, A. M.</creatorcontrib><creatorcontrib>Deurloo, E. E.</creatorcontrib><creatorcontrib>Slager, T. J. E.</creatorcontrib><creatorcontrib>Stoker, J.</creatorcontrib><creatorcontrib>Bipat, S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smets, A. M.</au><au>Deurloo, E. E.</au><au>Slager, T. J. E.</au><au>Stoker, J.</au><au>Bipat, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><addtitle>Pediatr Radiol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>48</volume><issue>2</issue><spage>241</spage><epage>252</epage><pages>241-252</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background
Many solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be unconditionally extrapolated to staging of children with malignant solid tumors.
Objective
To conduct a literature review on the sensitivity of WB-MRI for detecting skeletal metastases in children with solid tumors.
Materials and methods
Searches in MEDLINE and EMBASE databases up to 15 May 2017 were performed to identify studies on the diagnostic value of WB-MRI. Inclusion criteria were children and adolescents (age <21 years) with a primary solid tumor who were evaluated for skeletal metastases by WB-MRI and compared to any type of reference standard. The number of included patients had to be at least five and data on true positives, true negatives, false-positives and false-negatives had to be extractable.
Results
Five studies including 132 patients (96 patients with solid tumors) were eligible. Patient groups and used reference tests were heterogeneous, producing unclear or high risk of bias. Sensitivity of WB-MRI ranged between 82% and 100%. The positive predictive value of WB-MRI was variable among the studies and influenced by the used reference standard.
Conclusion
Although WB-MRI may seem a promising radiation-free technique for the detection of skeletal metastases in children with solid tumors, published studies are small and too heterogeneous to provide conclusive evidence that WB-MRI can be an alternative to currently used imaging techniques.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29151119</pmid><doi>10.1007/s00247-017-4013-8</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Adolescents Adults Biocompatibility Biomedical materials Children Diagnostic systems Imaging Imaging techniques Literature reviews Magnetic resonance imaging Medicine Medicine & Public Health Metastases Metastasis Neoplasms Neuroradiology NMR Nuclear magnetic resonance Nuclear Medicine Oncology Original Original Article Patients Pediatrics Radiation Radiology Resonance Sensitivity Solid tumors Tumors Ultrasound Young adults |
| title | Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review |
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