Tissue-Resident Lymphocytes in the Kidney

It has become evident that nonlymphoid tissues are populated by distinct subsets of innate and adaptive lymphocytes that are characterized by minimal exchange with recirculating counterparts. Especially at barrier sites, such as the skin, gut, and lung, these tissue-resident lymphocyte populations a...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2018-02, Vol.29 (2), p.389-399
Main Authors: Turner, Jan-Eric, Becker, Martina, Mittrücker, Hans-Willi, Panzer, Ulf
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Humans
Immunity, Innate
Immunologic Memory
Kidney - cytology
Kidney - immunology
Kidney Diseases - immunology
Killer Cells, Natural - immunology
Lymphocytes - immunology
Natural Killer T-Cells - immunology
T-Lymphocyte Subsets - immunology
Up Front Matters
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Summary:It has become evident that nonlymphoid tissues are populated by distinct subsets of innate and adaptive lymphocytes that are characterized by minimal exchange with recirculating counterparts. Especially at barrier sites, such as the skin, gut, and lung, these tissue-resident lymphocyte populations are ideally positioned to quickly respond to pathogens and other environmental stimuli. The kidney harbors several classes of innate and innate-like lymphocytes that have been described to contribute to this tissue-resident population in other organs, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T cells, and T cells. Additionally, a substantial proportion of the adaptive lymphocytes that are found in the kidney displays a surface phenotype suggestive of tissue residency, such as CD69 CD4 T cells. In this review, we summarize recent advances in the understanding of tissue-resident lymphocyte populations, review the available evidence for the existence of these populations in the kidney, and discuss the potential physiologic and pathophysiologic roles thereof in kidney.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2017060599