Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury

Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investiga...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2017-09, Vol.146 (3), p.369-374
Main Authors: Kayiran, Oguz, Cuzdan, Suat, Uysal, Afsin, Kocer, Ugur
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - administration & dosage
Antioxidants - administration & dosage
Apoptosis
Aqueous solutions
Care and treatment
Cytokines
Edema
Health aspects
Humans
Ischemia
Malondialdehyde - metabolism
Neutrophils
Original
Oxidative stress
Oxidative Stress - drug effects
Patient outcomes
Peroxidase - metabolism
Pyruvates
Pyruvates - administration & dosage
Rats
Reactive oxygen species
Reperfusion Injury - drug therapy
Reperfusion Injury - pathology
Reperfusion Injury - surgery
Sepsis
Skin - drug effects
Skin - pathology
Studies
Surgical Flaps - adverse effects
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Summary:Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P
ISSN:0971-5916
DOI:10.4103/ijmr.IJMR_1428_14