Concurrent eosinophilia and IgG4-related disease in a child: A case report and review of the literature

The current study presents the case of a 9-year-old Chinese boy who presented with eosinophilia and elevated serum levels of immunoglobulin G4 (IgG4). A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range,

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Published in:Experimental and therapeutic medicine 2018-03, Vol.15 (3), p.2739-2748
Main Authors: Chen, Can, Chen, Kuang, Huang, Xilian, Wang, Kaile, Qian, Shenxian
Format: Article
Language:English
Subjects:
Abdomen
Allergies
Blood diseases
Blood platelets
Bone marrow
Care and treatment
Case reports
Case studies
Development and progression
Disease
Eosinophilia
Growth factors
Leukemia
Lymphatic system
Pathogenesis
Patients
Polymerase chain reaction
Ultrasonic imaging
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cited_by cdi_FETCH-LOGICAL-c548t-7716ab6942da2e5b1535f0f45d235cda19eda4361ce2c0ff85a6ed906a9b1103
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container_end_page 2748
container_issue 3
container_start_page 2739
container_title Experimental and therapeutic medicine
container_volume 15
creator Chen, Can
Chen, Kuang
Huang, Xilian
Wang, Kaile
Qian, Shenxian
description The current study presents the case of a 9-year-old Chinese boy who presented with eosinophilia and elevated serum levels of immunoglobulin G4 (IgG4). A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range,
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A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range, &lt;5%), which indicated eosinophilia. However, gene analysis, fluorescent hybridization and other examinations, including bone marrow aspiration, blood routine, auto-antibody tests and parasitic and allergens screening, contradicted a diagnosis of secondary or clonal eosinophilia. Furthermore, the patient exhibited multiple lymph node swelling and a lymph biopsy strongly indicted a pathological diagnosis of IgG4-related disease (IgG4-RD). His peripheral blood flow cytometry confirmed an elevated count of plasmablasts, which is specific to IgG4-RD. The patient responded well to therapy with prednisone and remained healthy in all follow-ups. By taking all these factors into consideration, the boy was diagnosed with IgG4-RD. It is difficult to distinguish IgG4-RD from hypereosinophilic syndrome and the potential association between the two remains unclear. 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A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range, &lt;5%), which indicated eosinophilia. However, gene analysis, fluorescent hybridization and other examinations, including bone marrow aspiration, blood routine, auto-antibody tests and parasitic and allergens screening, contradicted a diagnosis of secondary or clonal eosinophilia. Furthermore, the patient exhibited multiple lymph node swelling and a lymph biopsy strongly indicted a pathological diagnosis of IgG4-related disease (IgG4-RD). His peripheral blood flow cytometry confirmed an elevated count of plasmablasts, which is specific to IgG4-RD. The patient responded well to therapy with prednisone and remained healthy in all follow-ups. By taking all these factors into consideration, the boy was diagnosed with IgG4-RD. It is difficult to distinguish IgG4-RD from hypereosinophilic syndrome and the potential association between the two remains unclear. 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subjects Abdomen
Allergies
Blood diseases
Blood platelets
Bone marrow
Care and treatment
Case reports
Case studies
Development and progression
Disease
Eosinophilia
Growth factors
Leukemia
Lymphatic system
Pathogenesis
Patients
Polymerase chain reaction
Ultrasonic imaging
title Concurrent eosinophilia and IgG4-related disease in a child: A case report and review of the literature
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