An experimental rabbit model of symptomatic cerebral vasospasm with in vivo neuroimaging assessment and ex vivo histological validation

Cerebral vasospasm (CVS) is a severe complication that occurs following aneurysmal subarachnoid hemorrhage (SAH). Magnetic resonance angiography (MRA) has been used to evaluate brain injury following SAH in humans. The present study was designed to assess a rabbit model of symptomatic CVS (SCVS) and...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-03, Vol.15 (3), p.2411-2417
Main Authors: Mo, Yunchang, Huang, Luping, Chen, Linbi, Veronesi, Michael, Shi, Yiyi, Chen, Sijia, Peng, Linli, Zhou, Leping, Pu, Yonglin, Wang, Junlu
Format: Article
Language:English
Subjects:
Brain damage
Care and treatment
Carotid arteries
Development and progression
Hemorrhage
Ischemia
Laboratory animals
Medical imaging
Medical research
Methods
Morbidity
Mortality
Neuroimaging
NMR
Nuclear magnetic resonance
Transient ischemic attack
Veins & arteries
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Summary:Cerebral vasospasm (CVS) is a severe complication that occurs following aneurysmal subarachnoid hemorrhage (SAH). Magnetic resonance angiography (MRA) has been used to evaluate brain injury following SAH in humans. The present study was designed to assess a rabbit model of symptomatic CVS (SCVS) and the utility of MRA in evaluating SCVS in rabbits. Japanese white rabbits (n=24) were randomly divided into 2 equal groups: A sham group and a SAH group. Neurological scores were evaluated for 7 days following SAH. Basilar artery (BA) diameters were measured using MRA preoperatively and 7 days postoperatively. Rabbits were sacrificed 7 days following SAH and the BA diameter of each rabbit was determined using histological evaluation. Compared with the Sham group, neurological function was significantly reduced in the SAH group at all time points (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.5690