Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs

To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divide...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2018, Vol.80(1), pp.59-62
Main Authors: SOMA, Takehisa, SAITO, Namiko, KAWAGUCHI, Masato, SASAI, Kazumi
Format: Article
Language:English
Subjects:
antibody
Cerebrospinal fluid
Coronaviridae
Coronaviruses
CSF
feline coronavirus
Feline infectious peritonitis
Peritonitis
Polymerase chain reaction
Ribonucleic acid
RNA
RT-PCR
Virology
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Summary:To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 1:80 or lower and 13 with CSF titer of 1:640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR. Our findings indicate that CSF titer of 1:640 or higher may be served as a candidate for the index for diagnosing FIP.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.17-0399