Accidental afloqualone intoxication in two dogs

Two dogs presented to the emergency service after accidental ingestion of afloqualone tablets, a muscle relaxant used for back pain in humans. Toxic effects of the drug in these dogs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria. Treatment consisted of fluid...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2018, Vol.80(1), pp.152-155
Main Authors: AHN, Jin-Ok, JAUNG, Won-Joung, WON, Sang-Heum, RYU, Min-Ok, SONG, Woo-Jin, JEON, Kee-Ok, CHUNG, Jin-Young, YOUN, Hwa-Young
Format: Article
Language:English
Subjects:
afloqualone
Ataxia
Back pain
Bradycardia
Butyric acid
canine
Diuresis
Flumazenil
Furosemide
Hematuria
Ingestion
Internal Medicine
Intoxication
Muscle relaxants
Muscles
Pain
Propofol
seizure
Seizures
Tablets
Toxicity
Vomiting
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Summary:Two dogs presented to the emergency service after accidental ingestion of afloqualone tablets, a muscle relaxant used for back pain in humans. Toxic effects of the drug in these dogs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria. Treatment consisted of fluid diuresis, furosemide, and propofol. Flumazenil, a gamma-amino butyric acid antagonist, was administered intravenously; however, it was not effective in stopping the seizures in these dogs. Both dogs recovered with supportive treatment. To the authors’ knowledge, this is the first documented report of afloqualone intoxication in dogs.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.17-0305