TRPA1 polymorphisms in chronic and complete spinal cord injury patients with neuropathic pain: a pilot study

• Published in: Spinal cord series and cases 2017-12, Vol.3 (1), p.17089-8, Article 17089
• Main Authors: Vidal Rodriguez, Sonia, Castillo Aguilar, Inmaculada, Cuesta Villa, Luis, Serrano Saenz de Tejada, Francisco
• Format: Article
• Language: English
• Subjects: 692/308/174; 692/499; Anatomy; Biomedical and Life Sciences; Biomedicine; Human Physiology; Neurochemistry; Neuropsychology; Neurosciences; Pain; Polymorphism; Spinal cord injuries
• ISSN: 2058-6124; 2058-6124
• DOI: 10.1038/s41394-017-0004-0

Study design Pilot study. Objectives Single-nucleotide polymorphisms (SNPs) in TRPA1 gene are related to the etiology of chronic pain. The study is a pilot study with the primary objective of analyzing these SNPs in Spanish patients with chronic and complete spinal cord injury (SCI) and neuropathic pain (NPP). Setting Asepeyo Hospital Department of Chronic and Complete SCI. Methods Twelve patients with chronic and complete SCI and NPP, and 12 patients with chronic and complete SCI with no pain were reviewed. International Spinal Cord Injury Pain Classification (LANSS) and visual analog score (VAS) were chosen to classify pain syndrome. SNPs were identified by melting analysis after DNA amplification with real-time fluorescence PCR. Results There were differences in rs11988795 variant: GG homozygous ( p  = 0.01) and G allele ( p  = 0.001) were more frequent in SCI patients with no pain. There were differences in rs13255063 variant: TT homozygous were prevalent ( p  = 0.03) in patients with NPP. Conclusions Until now this is the first study to show a description of TRPA1 SNPs in Spanish patients with chronic and complete SCI and NPP. These results suggest that GG genotype in rs11988795 variant and G allele could be protective factors against NPP. TT genotype in rs13255063 variant could be a risk factor for NPP. Neuropathic pain after spinal cord injuries may have genetic contributions.