Impact of liver volume on polycystic liver disease-related symptoms and quality of life

Background Symptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver. Aim The aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD. Methods We included PLD patients from two pr...

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Published in:United European gastroenterology journal 2018-02, Vol.6 (1), p.81-88
Main Authors: Neijenhuis, Myrte K, Kievit, Wietske, Verheesen, Stef MH, D’Agnolo, Hedwig M, Gevers, Tom JG, Drenth, Joost PH
Format: Article
Language:English
Subjects:
Autosomal dominant polycystic kidney disease (ADPKD)
autosomal dominant polycystic liver disease (ADPLD)
hepatomegaly
Original
quality of life
symptoms
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Summary:Background Symptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver. Aim The aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD. Methods We included PLD patients from two prospective studies that used the PLD-questionnaire (PLD-Q) for symptom assessment. QoL was assessed through SF-36, summarized in a physical (PCS) and mental (MCS) component score. Liver volume was correlated with PLD-Q total scores. Patients were classified based on height-corrected liver volume in mild (3200 ml) disease. PLD-Q and QoL (PCS and MCS) scores were compared across disease stages. Results We included 82 of 131 patients from the original studies (disease stages; mild n = 26, moderate n = 33, and severe n = 23). Patients with larger liver volume reported higher symptom burden (r = 0.516, p 
ISSN:2050-6406
2050-6414
DOI:10.1177/2050640617705577