Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

Highlights • VLP vaccine elicited high-titer antibodies specific for A/Anhui/1/2013 H7N9 virus. • VLP-immunized ferrets displayed protection against H7N9 virus. • H7N9 VLP vaccine was effective in protecting against lung and tracheal infection. • ISCOMATRIX or Matrix-M1 adjuvant improved protection...

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Bibliographic Details
Published in:Vaccine 2015-04, Vol.33 (18), p.2152-2158
Main Authors: Liu, Ye V, Massare, Michael J, Pearce, Melissa B, Sun, Xiangjie, Belser, Jessica A, Maines, Taronna R, Creager, Hannah M, Glenn, Gregory M, Pushko, Peter, Smith, Gale E, Tumpey, Terrence M
Format: Article
Language:English
Subjects:
adjuvants
Adjuvants, Immunologic
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Avian influenza
blood serum
China
Cholesterol - immunology
Cloning
death
Disease Models, Animal
Drug Combinations
Ferret
Ferrets
fever
hemagglutination
Hemagglutination Inhibition Tests
Hemagglutinin Glycoproteins, Influenza Virus - immunology
human diseases
Humans
Immunization
Immunogenicity
Infections
Influenza
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Manufacturing
Mustela
neutralizing antibodies
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Orthomyxoviridae Infections - virology
pandemic
Pandemics
Phospholipids - immunology
Public health
Respiratory distress syndrome
Saponins - immunology
Vaccination
Vaccine
Vaccines
Vaccines, Virus-Like Particle - administration & dosage
Vaccines, Virus-Like Particle - immunology
Viral Load
viral shedding
virion
Virus
virus-like particle vaccines
virus-like particles
Viruses
weight loss
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Items that cite this one
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Description
Summary:Highlights • VLP vaccine elicited high-titer antibodies specific for A/Anhui/1/2013 H7N9 virus. • VLP-immunized ferrets displayed protection against H7N9 virus. • H7N9 VLP vaccine was effective in protecting against lung and tracheal infection. • ISCOMATRIX or Matrix-M1 adjuvant improved protection of the VLP vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.03.009