Coronary microvascular dysfunction in diabetes mellitus

The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2017-12, Vol.45 (6), p.1901-1929
Main Authors: Kibel, Aleksandar, Selthofer-Relatic, Kristina, Drenjancevic, Ines, Bacun, Tatjana, Bosnjak, Ivica, Kibel, Dijana, Gros, Mario
Format: Article
Language:English
Subjects:
Algorithms
Coronary Vessels - physiopathology
Diabetes Mellitus - blood
Diabetes Mellitus - physiopathology
Endothelium, Vascular - physiopathology
Humans
Microcirculation
Microvessels - physiopathology
Special Issue: The Role of Vascular Dysfunction in Disease and Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.
ISSN:0300-0605
1473-2300
1473-2300
DOI:10.1177/0300060516675504