Coronary microvascular dysfunction in diabetes mellitus

The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes...

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Published in:Journal of international medical research 2017-12, Vol.45 (6), p.1901-1929
Main Authors: Kibel, Aleksandar, Selthofer-Relatic, Kristina, Drenjancevic, Ines, Bacun, Tatjana, Bosnjak, Ivica, Kibel, Dijana, Gros, Mario
Format: Article
Language:English
Subjects:
Algorithms
Coronary Vessels - physiopathology
Diabetes Mellitus - blood
Diabetes Mellitus - physiopathology
Endothelium, Vascular - physiopathology
Humans
Microcirculation
Microvessels - physiopathology
Special Issue: The Role of Vascular Dysfunction in Disease and Therapy
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cited_by cdi_FETCH-LOGICAL-c500t-6d5f494b465521c5b97210c22d2bb5edb3c540b670c117a28a9d43aecd0681d33
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container_end_page 1929
container_issue 6
container_start_page 1901
container_title Journal of international medical research
container_volume 45
creator Kibel, Aleksandar
Selthofer-Relatic, Kristina
Drenjancevic, Ines
Bacun, Tatjana
Bosnjak, Ivica
Kibel, Dijana
Gros, Mario
description The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.
doi_str_mv 10.1177/0300060516675504
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subjects Algorithms
Coronary Vessels - physiopathology
Diabetes Mellitus - blood
Diabetes Mellitus - physiopathology
Endothelium, Vascular - physiopathology
Humans
Microcirculation
Microvessels - physiopathology
Special Issue: The Role of Vascular Dysfunction in Disease and Therapy
title Coronary microvascular dysfunction in diabetes mellitus
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