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Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases

Background: Palpable thyroid nodules can be found in 4%-7% of the adult population; however,

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Published in:CytoJournal 2018-01, Vol.15 (1), p.3-3, Article 3
Main Author: Solmaz, Ozgen
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Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. Methods: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively. These aspirates were immunocytochemically stained for CD56. Results: In histopathological examination, the fine-needle aspiration cytopathology specimens suspicious for PTC (after undergoing surgery) showed that 32 (60.4%) were benign and 21 (39.6%) were malignant. Thirty-one of the benign cases (96.87%) were CD56-positive, whereas the last case (3.13%) was CD56-negative. Staining was not seen in any of the malignant cases. Conclusions: We believe that CD56 is an important marker in the definitive diagnosis of suspected PTC cases, with CD56-positivity being interpreted in favor of benignity.</description><identifier>ISSN: 1742-6413</identifier><identifier>ISSN: 0974-5963</identifier><identifier>EISSN: 1742-6413</identifier><identifier>EISSN: 0974-5963</identifier><identifier>DOI: 10.4103/cytojournal.cytojournal_42_17</identifier><identifier>PMID: 29497456</identifier><language>eng</language><publisher>United States: Wolters Kluwer India Pvt. Ltd</publisher><subject>Biopsy ; CD56 antigen ; Cellular biology ; Cytology ; Diagnosis ; Ethics ; Genetic aspects ; Immunohistochemistry ; Laboratories ; Medical research ; Needle biopsy ; Nodules ; Papillary thyroid carcinoma ; Pathology ; Statistical analysis ; Studies ; Thyroid ; Thyroid cancer ; Tumors ; Writers</subject><ispartof>CytoJournal, 2018-01, Vol.15 (1), p.3-3, Article 3</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2018 Solmaz, .; Licensee Cytopathology Foundation Inc. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c600t-f686335bd9753eb7eb300c946e888aaf945e098f975a3f8dbeb4c9689ef4f6633</citedby><cites>FETCH-LOGICAL-c600t-f686335bd9753eb7eb300c946e888aaf945e098f975a3f8dbeb4c9689ef4f6633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806416/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2101215351?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29497456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solmaz, Ozgen</creatorcontrib><title>Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases</title><title>CytoJournal</title><addtitle>Cytojournal</addtitle><description>Background: Palpable thyroid nodules can be found in 4%-7% of the adult population; however, &lt;5% of thyroid nodules are malignant. Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. Methods: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively. These aspirates were immunocytochemically stained for CD56. Results: In histopathological examination, the fine-needle aspiration cytopathology specimens suspicious for PTC (after undergoing surgery) showed that 32 (60.4%) were benign and 21 (39.6%) were malignant. Thirty-one of the benign cases (96.87%) were CD56-positive, whereas the last case (3.13%) was CD56-negative. Staining was not seen in any of the malignant cases. 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Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. Methods: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively. These aspirates were immunocytochemically stained for CD56. Results: In histopathological examination, the fine-needle aspiration cytopathology specimens suspicious for PTC (after undergoing surgery) showed that 32 (60.4%) were benign and 21 (39.6%) were malignant. Thirty-one of the benign cases (96.87%) were CD56-positive, whereas the last case (3.13%) was CD56-negative. Staining was not seen in any of the malignant cases. Conclusions: We believe that CD56 is an important marker in the definitive diagnosis of suspected PTC cases, with CD56-positivity being interpreted in favor of benignity.</abstract><cop>United States</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>29497456</pmid><doi>10.4103/cytojournal.cytojournal_42_17</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Biopsy
CD56 antigen
Cellular biology
Cytology
Diagnosis
Ethics
Genetic aspects
Immunohistochemistry
Laboratories
Medical research
Needle biopsy
Nodules
Papillary thyroid carcinoma
Pathology
Statistical analysis
Studies
Thyroid
Thyroid cancer
Tumors
Writers
title Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases
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