Prognostic value of HMGB1 and oxidative stress markers in multiple trauma patients: A single-centre prospective study

• Published in: International journal of immunopathology and pharmacology 2016-09, Vol.29 (3), p.504-509
• Main Authors: Polito, Francesca, Cicciu’, Marco, Aguennouz, Mohammed, Cucinotta, Maria, Cristani, Mariateresa, Lauritano, Floriana, Sindoni, Alessandro, Gioffre’-Florio, Maria, Fama, Fausto
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biomarkers; Biomarkers - metabolism; Complications; Female; HMGB1 protein; HMGB1 Protein - metabolism; Humans; Letters to the Editor; Male; Middle Aged; Multiple Trauma - metabolism; Multiple Trauma - pathology; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Oxidative Stress - physiology; Patients; Prognosis; Prospective Studies; Severity of Illness Index; Trauma; Young Adult
• ISSN: 2058-7384; 0394-6320; 2058-7384
• DOI: 10.1177/0394632016656187

Serious multiple traumatic injuries may rapidly become fatal or be complicated by a life-threatening sequelae leading to a significant increase of the mortality rate. Trauma scoring systems are used to evaluate the critical status of the patient and recently many different biomarkers have been taken into account to better estimate the potential clinical outcome. The aim of the present study is to analyse the expression pattern of high-mobility group box-1 (HMGB1), oxidative stress markers and nuclear factor erythroid 2-related (Nrf2) in critically ill traumatic patients (at hospital admittance and after 6 and 24 h), in order to find out their potential role as early post-traumatic predictors markers. Forty-seven patients admitted for multiple trauma and 15 healthy participants were prospectively recruited. Eight patients (17%) died within 92 h of admission; this subgroup of patients presented the highest severity scores and their HMGB1 expression levels were significantly correlated with ISS, whereas patients with higher ISS exhibited higher levels of HMGB1 (P