Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers

Purpose Previous research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk in BRCA1 and BRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the gener...

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Bibliographic Details
Published in:Breast cancer research and treatment 2018-02, Vol.167 (3), p.779-785
Main Authors: Evans, DG, Harkness, EF, Howel, S., Woodward, ER, Howell, A., Lalloo, F.
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Age of Onset
BRCA1 protein
BRCA1 Protein - genetics
BRCA2 protein
BRCA2 Protein - genetics
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer genetics
Cancer research
Development and progression
England
Epidemiology
Female
Gene mutation
Genetic aspects
Genetic Predisposition to Disease
Health aspects
Health risk assessment
Hormone replacement therapy
Humans
Medicine
Medicine & Public Health
Middle Aged
Mutation
Oncology
Pregnancy
Pregnant women
Risk Assessment
Studies
Young Adult
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Summary:Purpose Previous research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk in BRCA1 and BRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the general population of women. The present study addresses these inconsistencies. Methods Female BRCA1 and BRCA2 carriers from North West England were assessed for breast cancer incidence prior to 50 years of age comparing those with an early first full-term pregnancy (
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-017-4557-1