“Double carbapenem” and oral fosfomycin for the treatment of complicated urinary tract infections caused by blaNDM‐harboring Enterobacteriaceae in kidney transplantation

Infections with carbapenemase‐producing carbapenem‐resistant Enterobacteriaceae represent an emergent problem worldwide. Treatment of infections caused by New Delhi metallo‐beta‐lactamase (NDM)‐harboring Enterobacteriaceae is particularly challenging as it frequently involves the use of nephrotoxic...

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Bibliographic Details
Published in:Transplant infectious disease 2018-02, Vol.20 (1), p.n/a
Main Authors: Rosa, Rossana, Rudin, Susan D., Rojas, Laura J., Hujer, Andrea M., Perez‐Cardona, Armando, Perez, Federico, Bonomo, Robert A., Martinez, Octavio, Abbo, Lilian M., Camargo, Jose F.
Format: Article
Language:English
Subjects:
Antibiotics
Carbapenemase
carbapenem‐resistant Enterobacteriaceae
Enterobacteriaceae
Fosfomycin
Health risk assessment
kidney transplant
Kidney transplantation
Kidney transplants
Metallography
NDM
Transplantation
Transplants & implants
Urinary tract
Urinary tract diseases
Urinary tract infections
Urogenital system
β Lactamase
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Summary:Infections with carbapenemase‐producing carbapenem‐resistant Enterobacteriaceae represent an emergent problem worldwide. Treatment of infections caused by New Delhi metallo‐beta‐lactamase (NDM)‐harboring Enterobacteriaceae is particularly challenging as it frequently involves the use of nephrotoxic agents, which is problematic in kidney transplant recipients and non‐renal transplant patients with marginal kidney function. We present two cases of urinary tract infections caused by NDM‐harboring Enterobacteriaceae successfully treated with a combination of “double carbapenem” and oral fosfomycin.
ISSN:1398-2273
1399-3062
1399-3062
DOI:10.1111/tid.12795