Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population

The Sysmex XN-series haematology analyser has newly adopted a fluorescent channel to measure immature platelet fraction (IPF). To promote the clinical utility of this promising parameter, establishing a reliable reference interval is mandatory. According to previous studies, IPF values may be affect...

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Bibliographic Details
Published in:Biochemia Medica 2018-02, Vol.28 (1), p.010708-010708
Main Authors: Imperiali, Claudia E, Arbiol-Roca, Ariadna, Sanchez-Navarro, Lourdes, Dastis-Arias, Macarena, Lopez-Delgado, Juan C, Cortes-Bosch, Anna, Sancho-Cerro, Ana, Dot-Bach, Dolors
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Cell Count - instrumentation
Blood Cell Count - methods
Blood Cell Count - standards
Blood Platelets - cytology
Female
haematology
Healthy Volunteers
Hemoglobins - analysis
Humans
immature platelet fraction
Male
Middle Aged
Original Papers
Platelet Count - standards
platelets
Reference Values
Young Adult
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Summary:The Sysmex XN-series haematology analyser has newly adopted a fluorescent channel to measure immature platelet fraction (IPF). To promote the clinical utility of this promising parameter, establishing a reliable reference interval is mandatory. According to previous studies, IPF values may be affected by the employed analyser and the ethnic background of the individual, but no differences seem to be found between individuals' genders. Therefore, this study aimed to define the reference interval for IPF in a Spanish population following Clinical and Laboratory Standard Institute (CLSI) guidelines. A total of 153 healthy Caucasian adults from Spain met the inclusion criteria. IPF measurement was performed by means of a Sysmex XN-2000 haematology analyser. A non-parametric percentile method was used to calculate the reference intervals in accordance with CLSI guidelines. The obtained reference interval for IPF on the Sysmex XN-2000 was 1.6-9.6% (90% confidence intervals (CIs) were 1.5-1.8 and 9.3-11.5, respectively). No significant gender difference in IPF reference intervals was observed (P = 0.101). This study provides, for the first time, a reference interval for IPF using a Sysmex XN-2000 in a Spanish population, ranging from 1.6 to 9.6%. These data are needed to evaluate platelet production in several conditions such as thrombocytopenia, inflammatory states and cardiovascular diseases, as well as for future research.
ISSN:1330-0962
1846-7482
DOI:10.11613/BM.2018.010708