Influence of metabolic syndrome and race on the relationship between intensive blood pressure control and cardiovascular outcomes in the SPRINT cohort

• Published in: Diabetes, obesity & metabolism obesity & metabolism, 2018-03, Vol.20 (3), p.629-637
• Main Authors: Dungan, Kathleen, Craven, Timothy E., Soe, Kyaw, Wright, Jackson T., Basile, Jan, Haley, William E., Kressin, Nancy R., Rani, Uzma, Tamariz, Leonardo, Whittle, Jeff, Wiggers, Alan, Osei, Kwame
• Format: Article
• Language: English
• Subjects: Aged; Antihypertensive Agents - therapeutic use; Blood pressure; Blood Pressure - physiology; Body mass index; cardiovascular disease; Cardiovascular system; Cerebral infarction; clinical trial; Continental Population Groups - ethnology; Early Termination of Clinical Trials; Ethnicity; Female; glucose metabolism; Heart attacks; Heart diseases; Heart Failure - ethnology; Heart Failure - mortality; Hispanic people; Humans; Hypertension - ethnology; Hypertension - mortality; Hypertension - prevention & control; Insulin resistance; macrovascular disease; Male; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - ethnology; Metabolic Syndrome - mortality; Minority & ethnic groups; Myocardial infarction; Myocardial Infarction - ethnology; Myocardial Infarction - mortality; Race Factors; randomized trial; Stroke - ethnology; Stroke - mortality; United States - epidemiology
• ISSN: 1462-8902; 1463-1326
• DOI: 10.1111/dom.13127

Aims To determine whether baseline metabolic syndrome (MetS) modifies the effect of intensive blood pressure control on cardiovascular (CV) outcomes, and whether the effects varied by race/ethnicity. Methods We performed post hoc analyses among non‐Hispanic black, non‐hispanic white and Hispanic participants, with and without MetS, in the Systolic Blood Pressure Intervention Trial (SPRINT), who were randomized to a systolic blood pressure (SBP) target of