Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative

• Published in: European radiology 2018-03, Vol.28 (3), p.953-962
• Main Authors: Guimaraes, Julio Brandao, Nevitt, Michael C., McCulloch, Charles E., Schwaiger, Benedikt J., Gersing, Alexandra S., Facchetti, Luca, Bucknor, Matthew D., Chanchek, Nattagan, Liu, Felix, Joseph, Gabby B., Link, Thomas M.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Body Weight - physiology; Body weight loss; Computer worms; Confidence intervals; Degeneration; Diagnostic Radiology; Disease Progression; Female; Humans; Imaging; Injuries; Internal Medicine; Interventional Radiology; Knee; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Menisci; Menisci, Tibial - pathology; Meniscus; Middle Aged; Musculoskeletal; Neuroradiology; Osteoarthritis; Osteoarthritis - diagnosis; Radiology; Statistical analysis; Tearing; Ultrasound; Variance analysis
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-017-5054-y

Objectives To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). Methods We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (≥3%, n = 141), had moderate weight gain (3–10%, n = 77), substantial weight gain (>10%, n = 15) or maintained stable weight ( n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects’ characteristics. Results Progression of MID increased from weight loss to substantial weight gain ( p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9; 95% confidence interval [CI] 2.4–8.9) and substantial weight gain (OR, 9.5; 95% CI 3.2–28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8; 95% CI 3.5–11.3; lateral: OR, 2.6; 95% CI 1.1–6.6) and substantial weight gain (medial: OR, 21.0; 95% CI 5.1–80.7; lateral: OR, 9.7; 95% CI 0.95–100.2). Conclusion Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain. Key Points • Subjects who gained weight were more likely to develop meniscal tears. • Greater amount of weight gain was associated with an increasing likelihood of progression. • Prevention of weight gain has health benefits for the meniscus.