In vitro cytotoxicity activity of novel Schiff base ligand–lanthanide complexes

A Schiff base ligand (SBL), N 2 , N 3 -bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio. 1 H NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL....

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Bibliographic Details
Published in:Scientific reports 2018-02, Vol.8 (1), p.3054-12, Article 3054
Main Authors: Andiappan, Kavitha, Sanmugam, Anandhavelu, Deivanayagam, Easwaramoorthy, Karuppasamy, K., Kim, Hyun-Seok, Vikraman, Dhanasekaran
Format: Article
Language:English
Subjects:
13/2
140/131
631/45/56
639/638/309/2144
Anthracene
Breast cancer
Cervical cancer
Cervix
Cytotoxicity
Erbium
Fluorescence spectroscopy
Fourier transforms
Humanities and Social Sciences
Ligands
Metal complexes
Metal ions
Metals
multidisciplinary
NMR
Nuclear magnetic resonance
Praseodymium
Pyridines
Science
Science (multidisciplinary)
Spectrum analysis
Ytterbium
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Summary:A Schiff base ligand (SBL), N 2 , N 3 -bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio. 1 H NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL. A novel series of lanthanide (i.e., praseodymium (Pr), erbium (Er), and ytterbium (Yb))-based SBL metal complexes was successfully synthesized, and their functional groups were elaborately demonstrated using UV–visible, Fourier transform infrared (FT-IR), and fluorescence spectroscopy analyses. FT-IR spectral studies revealed that SBL behaved as a bidentate ligand and it was structured with metal ions by the two azomethine nitrogens. The synthesized SBL-based metal complexes were elaborately performed for cytotoxicity activity versus Vero, human breast cancer (MCF7), and cervical (HeLa) anticancer cell lines.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-21366-1