Recurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man

•Typical HV is a self-limited EBV-associated disorder of children and adolescents characterized by recurrent outbreaks of scarring papulovesicular lesions. The criterion standard diagnostic test is biopsy of an active lesion showing reticular degeneration and demonstrating EBV RNA (EBER positivity)...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2018-03, Vol.78 (3), p.637-642
Main Authors: Levoska, Melissa A., Cohen, Jeffrey I., Manoli, Irini, Richard Lee, Chyi-Chia, Ching, Steven S.T., Shand, Jessica, Tamura, Deborah, Kraemer, Kenneth H., DiGiovanna, John J.
Format: Article
Language:English
Subjects:
Blister - etiology
Bone Diseases, Metabolic - etiology
Chronic Disease
Cicatrix - etiology
EBV-associated lymphoproliferative disorders
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - diagnosis
Humans
hydroa vacciniforme
Hydroa Vacciniforme - complications
Hydroa Vacciniforme - diagnosis
Hydroa Vacciniforme - prevention & control
Male
photodermatosis
photosensitivity
Recurrence
Sunlight - adverse effects
Vitamin D Deficiency - complications
Young Adult
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Summary:•Typical HV is a self-limited EBV-associated disorder of children and adolescents characterized by recurrent outbreaks of scarring papulovesicular lesions. The criterion standard diagnostic test is biopsy of an active lesion showing reticular degeneration and demonstrating EBV RNA (EBER positivity) in lymphocytes.•Avoiding sun exposure by using photoprotection can reduce outbreaks.•Patients typically have high levels of circulating EBV DNA, which is best detected from whole blood rather than from serum or plasma.•In patients with persistent skin disease activity, following EBV DNA levels in the blood can help assess for the development of aggressive systemic disease.•Severe HV disease associated with chronic active EBV may progress to lymphoproliferative disorders or lymphoma with increased mortality.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2017.08.005