Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury

Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. We have previously reported the remarkable gastroprotective and anti-Helicobacter pylori activities of the methanolic extract (CpMet) of Cyrtocarpa procera bark. This work i...

Full description

Saved in:
Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Cardoso-Taketa, Alexandre, Guerrero Alquicira, Raquel, García-Martínez, Karina, Gomez-Chang, Erika, Escobedo-Hinojosa, Wendy Itzel, Romero, Irma
Format: Article
Language:English
Subjects:
Alcohol
Alcohol, Denatured
Animal models
Antibiotics
Antiulcer drugs
Bark
Calotropis procera
Drugs
Ethanol
Helicobacter pylori
Inflammation
Metronidazole
Mucin
Mucosa
Nitric oxide
Oils & fats
Oral administration
Pathogenesis
Pharmacology
Physiology
Phytochemicals
Prostaglandins
Rodents
Sulfhydryl groups
Toxicity
Ulcers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. We have previously reported the remarkable gastroprotective and anti-Helicobacter pylori activities of the methanolic extract (CpMet) of Cyrtocarpa procera bark. This work investigates, in a murine model, the CpMet gastroprotective mechanism and establishes its preclinical efficacy in the resolution of ethanol-induced gastric ulcers. The results showed that the gastroprotective activity of CpMet is mainly associated with endogenous NO and prostaglandins, followed by sulfhydryl groups and KATP channels. Furthermore, CpMet (300 mg/kg, twice a day) orally administered during 20 consecutive days promoted an ulcer area reduction of 62.65% at the 20th day of the treatment. The effect was confirmed macroscopically by the alleviation of gastric mucosal erosions and microscopically by an increase in mucin content and a reduction in the inflammatory infiltration at the site of the ulcer. No clinical symptoms or signs of toxicity were observed in the treated animals. The results indicate the safety and efficacy of CpMet in promoting high quality of ulcer healing by different mechanisms, but mostly through cytoprotective and anti-inflammatory effects, making it a promising phytodrug for ulcer treatment.
ISSN:1741-427X
1741-4288
DOI:10.1155/2018/2862706